Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCR All Species: 31.82
Human Site: T347 Identified Species: 50
UniProt: P04035 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P04035 NP_000850.1 888 97476 T347 E Q T E T E S T L S L K N P I
Chimpanzee Pan troglodytes XP_001148324 888 97313 T347 E Q T E T E S T L S L K N P I
Rhesus Macaque Macaca mulatta XP_001104607 888 97210 T347 E Q A E T E S T L S L K N P I
Dog Lupus familis XP_536323 888 97475 T347 E Q A E T E S T L S L K N P I
Cat Felis silvestris
Mouse Mus musculus Q01237 887 97003 T347 E Q A E T E S T L S L K N P I
Rat Rattus norvegicus P51639 887 96670 T347 E Q A E T E S T L S L K N P I
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_989816 875 95421 T345 L S L K N P I T S P V T V Q K
Frog Xenopus laevis P20715 883 96702 T349 E Q T E T E S T F S M K N P I
Zebra Danio Brachydanio rerio NP_001119931 893 97691 T348 E Q V E M E S T L S L K V P T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P14773 920 98299 R395 D P L P D Q L R Q S G P V A I
Honey Bee Apis mellifera XP_623118 908 99432 Q350 D K E D I A K Q L Q F K V E D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus P16393 932 100947 E346 S D L A T Y P E K R V S I M E
Poplar Tree Populus trichocarpa
Maize Zea mays O24594 579 60912 I103 G I A F V Q S I V S S G D D D
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P14891 592 63579 F116 L G F F G I D F V Q S F I S R
Baker's Yeast Sacchar. cerevisiae P12683 1054 115607 S492 L L L L R N V S V A I R D R F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 98.7 95.7 N.A. 93.3 92.7 N.A. N.A. 85.1 80.9 77.8 N.A. 47.2 51.2 N.A. 56.3
Protein Similarity: 100 99.7 99.3 97.3 N.A. 96 95.8 N.A. N.A. 91.6 89.5 86.7 N.A. 64.6 69.2 N.A. 70.6
P-Site Identity: 100 100 93.3 93.3 N.A. 93.3 93.3 N.A. N.A. 6.6 86.6 73.3 N.A. 13.3 13.3 N.A. 6.6
P-Site Similarity: 100 100 93.3 93.3 N.A. 93.3 93.3 N.A. N.A. 20 93.3 73.3 N.A. 26.6 33.3 N.A. 13.3
Percent
Protein Identity: N.A. 33.5 N.A. 34.5 35.1 N.A.
Protein Similarity: N.A. 46.8 N.A. 47.5 51 N.A.
P-Site Identity: N.A. 13.3 N.A. 0 0 N.A.
P-Site Similarity: N.A. 33.3 N.A. 6.6 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 34 7 0 7 0 0 0 7 0 0 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 14 7 0 7 7 0 7 0 0 0 0 0 14 7 14 % D
% Glu: 54 0 7 54 0 54 0 7 0 0 0 0 0 7 7 % E
% Phe: 0 0 7 14 0 0 0 7 7 0 7 7 0 0 7 % F
% Gly: 7 7 0 0 7 0 0 0 0 0 7 7 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 0 0 7 7 7 7 0 0 7 0 14 0 54 % I
% Lys: 0 7 0 7 0 0 7 0 7 0 0 60 0 0 7 % K
% Leu: 20 7 27 7 0 0 7 0 54 0 47 0 0 0 0 % L
% Met: 0 0 0 0 7 0 0 0 0 0 7 0 0 7 0 % M
% Asn: 0 0 0 0 7 7 0 0 0 0 0 0 47 0 0 % N
% Pro: 0 7 0 7 0 7 7 0 0 7 0 7 0 54 0 % P
% Gln: 0 54 0 0 0 14 0 7 7 14 0 0 0 7 0 % Q
% Arg: 0 0 0 0 7 0 0 7 0 7 0 7 0 7 7 % R
% Ser: 7 7 0 0 0 0 60 7 7 67 14 7 0 7 0 % S
% Thr: 0 0 20 0 54 0 0 60 0 0 0 7 0 0 7 % T
% Val: 0 0 7 0 7 0 7 0 20 0 14 0 27 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _